Three rectangles paste on a khaki backgroud. The largest one on the top right of the board contains a portrait of scientific sleuth Sholto David, with a dot on its top right corner. The middle left one slightly overlaps the first rectangle and contains a photo of scientific sleuth Elizabeth Bik, with a dot on its bottom left corner. The smallest one on the bottom also slightly overlaps the second rectangle and contains a photo of scientific sleuth Kevin Patrick, with a dot on its bottom right corner -- who to know coverage from STAT
Top to bottom: Sholto David, Elisabeth Bik, Kevin Patrick.Photo illustration: Christine Kao/STAT; Photos: Francesca Jones, Brian L. Frank, Kevin Patrick

Researchers like to say that science is self-correcting, that knowledge is slowly but surely refined by new findings that build on or debunk old ones. But this process is far from perfect and is hampered by sloppy experiments or, in some cases, faked results.

A small, tight-knit community of scientific sleuths has been unearthing growing evidence that many studies, including landmark papers published in top journals, contain manipulated images and falsified findings. These revelations have led to high-profile investigations, raised concerns about clinical trials, and culminated in the departure of university presidents

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Their work — often posted on PubPeer, a website where users comment on published studies — has also forced a reckoning around how the crushing pressure to publish splashy results incentivizes fraud, a conversation research integrity experts say is both deeply uncomfortable and long overdue.

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