Pat Greenhouse/Globe Staff

The Broad Institute of MIT and Harvard, one of the most prominent biotech research centers in the world, has laid off 87 employees, a spokesperson confirmed.

The layoffs came as a lucrative partnership with Microsoft was expected to conclude at the end of the year.

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In an email to staff Thursday, Todd Golub, the Broad’s director, attributed the cuts to the “rapid pace of technological and scientific change [which] requires us to retool to stay ahead” in the institute’s field.

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